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Serum and cerebrosp...
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes.
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Paterson, Ross W (author)
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Benjamin, Laura A (author)
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Mehta, Puja R (author)
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Brown, Rachel L (author)
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Athauda, Dilan (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Leckey, Claire A (author)
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Ziff, Oliver J (author)
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Heaney, Judith (author)
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Heslegrave, Amanda J (author)
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- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Checkley, Anna M (author)
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Houlihan, Catherine F (author)
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Mummery, Catherine J (author)
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Lunn, Michael P (author)
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Manji, Hadi (author)
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Zandi, Michael S (author)
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Keddie, Stephen (author)
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Chou, Michael (author)
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Vinayan Changaradil, Deepthi (author)
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Solomon, Tom (author)
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Keshavan, Ashvini (author)
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Barker, Suzanne (author)
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Jäger, Hans Rolf (author)
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Carletti, Francesco (author)
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Simister, Robert (author)
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Werring, David J (author)
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Spyer, Moira J (author)
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Nastouli, Eleni (author)
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Gauthier, Serge (author)
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Rosa-Neto, Pedro (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, Jonathan M (author)
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(creator_code:org_t)
- 2021-05-12
- 2021
- English.
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In: Brain communications. - : Oxford University Press (OUP). - 2632-1297. ; 3:3
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (n = 34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n = 94) and without (n = 24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14 800 pg/ml (400, 32 400)], compared to those with encephalopathy [1410 pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740 pg/ml (507, 881)] and controls [872 pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- ADEM
- COVID-19
- NfL
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Paterson, Ross W
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Benjamin, Laura ...
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Mehta, Puja R
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Brown, Rachel L
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Athauda, Dilan
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Ashton, Nicholas ...
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show more...
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Leckey, Claire A
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Ziff, Oliver J
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Heaney, Judith
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Heslegrave, Aman ...
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Lessa Benedet, A ...
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Blennow, Kaj, 19 ...
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Checkley, Anna M
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Houlihan, Cather ...
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Mummery, Catheri ...
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Lunn, Michael P
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Manji, Hadi
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Zandi, Michael S
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Keddie, Stephen
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Chou, Michael
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Vinayan Changara ...
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Solomon, Tom
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Keshavan, Ashvin ...
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Barker, Suzanne
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Jäger, Hans Rolf
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Carletti, France ...
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Simister, Robert
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Werring, David J
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Spyer, Moira J
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Nastouli, Eleni
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Gauthier, Serge
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Rosa-Neto, Pedro
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Zetterberg, Henr ...
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Schott, Jonathan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Brain communicat ...
- By the university
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University of Gothenburg